Aplikasi Teknologi Nanopartikel Pada Pengobatan Kanker

Main Article Content

Handika Nur Arofik
Bayyinatul Muchtaromah

Abstract

Kanker merupakan salah satu penyakit penyebab kematian di dunia. Hingga saat ini kanker masih menjadi salah satu masalah kesehatan yang cukup kompleks. Pemanfaatan nanopartikel dalam pengobatan kanker bertujuan untuk meningkatkan bioavailabilitas dan distribusi obat, serta memperbaiki targeting dan release obat ke sel tumor, sehingga diharapkan dapat meningkatkan efikasi dan mengurangi efek samping. Nanopartikel merupakan semua bentuk material biologis dan sintetik yang dimensinya < 1µm. Nanopartikel dalam penatalaksanaan kanker dikembangkan sebagai drugdelivery vehicle (carrier), contrast agent (imaging), diagnostic device, platform untuk theranostic agents, antioksidan, in vivo tumor targeting dengan spesifisitas dan afinitas yang tinggi, serta sebagai probe pada riset preklinik untuk studi molekuler penyakit. Tujuan review artikel ini adalah untuk mengetahui penggunaan nanopartikel dalam pengobatan kanker. Berdasarkan penelitian menunjukan bahwa nanopartikel dapat menjadi penghantaran obat yang terkontrol dan dapat disesuaikan pada pengobatan kanker.

Downloads

Download data is not yet available.

Article Details

How to Cite
Nur Arofik, H., & Muchtaromah, B. (2023). Aplikasi Teknologi Nanopartikel Pada Pengobatan Kanker. ULIL ALBAB : Jurnal Ilmiah Multidisiplin, 2(4), 1578–1585. https://doi.org/10.56799/jim.v2i4.1464
Section
Articles

References

Ariani, S. (2015). Stop kanker. Yogyakarta: Istana Media.

Boraschi, D., Costantino, L., & Italiani, P. (2012). Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. Nanomedicine, 7(1), 121-131.

Dreaden, E. C., Austin, L. A., Mackey, M. A., & El-Sayed, M. A. (2012). Size matters: gold nanoparticles in targeted cancer drug delivery. Therapeutic delivery, 3(4), 457-478.

Emeje, M. O., Obidike, I. C., Akpabio, E. I., & Ofoefule, S. I. (2012). Nanotechnology in drug delivery. Recent advances in novel drug carrier systems, 1(4), 69-106.

Hanutami, Berlian, and Arif Budiman. (2017). Penggunaan Teknologi Nano Pada Formulasi Obat Herbal. Farmaka 15: 29–39.

Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H. & Weissleder, R. (2003). Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. New England Journal of Medicine, 348(25), 2491-2499.

Hu, C. M. J., Aryal, S., & Zhang, L. (2010). Nanoparticle-assisted combination therapies for effective cancer treatment. Therapeutic delivery, 1(2), 323-334.

Jain, S., & Das, M. (2011). Conference scene: nanomedicine kindles the development of the‘elixir of life’. Nanomedicine, 6(4), 599-603.

Juliano, R. (2007). Bugging tumors to put drugs on target. New England Journal of Medicine, 356(9), 954-955.

Keen, J. C. (2008). A step towards a new targeted nanotherapy for pancreatic cancer. Cancer Biology & Therapy, 7(10), 1591-1592.

Kim, Betty Y S, James T. Rutka, and Warren C W Chan. (2010). Nanomedicine. The New England journal of medicine 363(25): 2434–43.

Muthiah, M., Che, H. L., Kalash, S., Jo, J., Choi, S. Y., Kim, W. J., & Park, I. K. (2015). Formulation of glutathione responsive anti-proliferative nanoparticles from thiolated Akt1 siRNA and disulfide-crosslinked PEI for efficient anti-cancer gene therapy. Colloids and Surfaces B: Biointerfaces, 126, 322-327.

Muthu, M. S., & Wilson, B. (2010). Multifunctional radionanomedicine: a novel nanoplatform for cancer imaging and therapy. Nanomedicine, 5(2), 169-171.

Nie, S. (2010). Understanding and overcoming major barriers in cancer nanomedicine. Nanomedicine, 5(4), 523-528.

Peng, W., Dunton, C., Holtz, D., Parva, M., Stampler, K., Forwood, M., & Sawicki, J. A. (2013). DNA nanotherapy for pre-neoplastic cervical lesions. Gynecologic oncology, 128(1), 101-106.

Podila, R., & Brown, J. M. (2013). Toxicity of engineered nanomaterials: a physicochemical perspective. Journal of biochemical and molecular toxicology, 27(1), 50-55.

Pusat Data dan Informasi Kementerian. (2015). Situasi Penyakit Kanker. Journal of Chemical Information and Modeling 53(9): 1689–99.

Rahmi, D. (2010). Lemak padat nanopartikel; sintesis dan aplikasi. Jurnal Kimia dan Kemasan, 32(1), 27-33.

Raut, I. D., Doijad, R. C., Mohite, S. K., & Manjappa, A. S. (2018). Preparation and Characterization of Solid Lipid Nanoparticles Loaded with Cisplatin. Journal of Drug Delivery and Therapeutics, 8(6), 125-131.

Roselle, L., Spray, S., & Shelton, J. T. (2019). Research and writing in international relations. https://doi.org/10.4324/9780429446733

Saba, N. F., Wang, X., Müller, S., Tighiouart, M., Cho, K., Nie, S., & Shin, D. M. (2009). Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug. Head & neck, 31(4), 475-481.

Sapra, M., Mayya, Y. S., & Venkataraman, C. (2017). Engineering of layered, lipid-encapsulated drug nanoparticles through spray-drying. Colloids and Surfaces B: Biointerfaces, 154, 178-185.

Schellekens, R. C., Baltink, J. H., Woesthuis, E. M., Stellaard, F., Kosterink, J. G., Woerdenbag, H. J., & Frijlink, H. W. (2012). Film coated tablets (ColoPulse technology) for targeted delivery in the lower intestinal tract: Influence of the core composition on release characteristics. Pharmaceutical development and technology, 17(1), 40-47.

Shanker, M., Jin, J., Branch, C. D., Miyamoto, S., Grimm, E. A., Roth, J. A., & Ramesh, R. (2011). Tumor suppressor gene-based nanotherapy: from test tube to the clinic. Journal of drug delivery, 2011.

Son, S. J., Bai, X., & Lee, S. B. (2007). Inorganic hollow nanoparticles and nanotubes in nanomedicine: Part 1. Drug/gene delivery applications. Drug discovery today, 12(15-16), 650-656.

Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015). Global cancer statistics, 2012. CA: a cancer journal for clinicians, 65(2), 87-108.

Velavan, P., C.Karuppusamy dan P. Venkatesen. (2015). Nanoparticles as Drug Delivery Systems. Journal of Pharmaceutical Sciences and Research. Vol. 7(12), 2015, 1118-1122.

World Health Organization. (2007). Cancer control: knowledge into action. WHO guide for effective programmes. Early detection. Cancer control: knowledge into action. WHO guide for effective programmes. Early detection.

Yadav, N., Khatak, S., and Sara, U. S. (2013). Solid Lipid Nanoparticles- A Review. International Journal of Applied Pharmaceutics 5(2): 8–18.